The African Wild Dog is endangered by human overpopulation, habitat loss and hunting, and their collection from the wild by wild animal dealers.

It uses very large territories (and so can persist only in large wildlife protected areas), and it is strongly affected by competition with larger carnivores that rely on the same prey base, particularly the lion and the Spotted Hyena. Lions often will kill as many wild dogs as they can but do not eat them. Hyenas usually follow them to steal their kills. One on one the hyena is much more powerful than the Wild Dog but a large group of Wild Dogs can successfully chase off a small number of hyenas because of their teamwork. It is also killed by livestock herders and game hunters, though it is typically no more (perhaps less) persecuted than other carnivores that pose more threat to livestock.

Most of Africa’s national parks are too small for a pack of wild dogs, so the packs expand to the unprotected areas, which tend to be ranch or farm land. Ranchers and farmers protect their domestic animals by killing the wild dogs.

Like other carnivores, the African Wild Dog is sometimes affected by outbreaks of viral diseases such as rabies, distemper, and parvovirus. Although these diseases are not more pathogenic or virulent for wild dogs, the small size of most wild dog populations makes them vulnerable to local extinction due to diseases or other problems.